Brain & sleep · Compound guide
PE-22-28 Research Guide
Explore the mechanisms, study findings and evidence limits behind this research topic.
Product artwork identifies the SRP listing. It does not demonstrate safety or clinical benefit. The evidence guide and its sources follow below.
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Cell-channel and mouse behavioral research
Evidence reviewed September 13, 2026.
Research overview and identity
PE-22-28 is a shortened spadin-related peptide investigated in neuroscience research. It is a seven-amino-acid experimental compound, and its modified derivatives should be distinguished from the parent PE-22-28 sequence.
Mechanism under investigation
A primary research program examined inhibition of the TREK-1 potassium channel using electrophysiological assays. A measured channel effect is a mechanistic observation; it does not independently establish an antidepressant effect in humans.
What the studies report
A 2017 study tested PE-22-28 and derivatives in engineered cells, mouse behavioral models and neuronal assays. It reported TREK-1 inhibition and changes in behavioral and neuronal markers. Terminal changes and other modifications affected activity, making the exact tested structure important. [1]
Limits of the evidence
Mouse behavioral tests do not reproduce the full complexity of clinical depression. The cited work is preclinical and does not establish human effectiveness, onset, duration or long-term safety. Results for optimized derivatives should not be assigned to every PE-22-28 preparation.
Matching research material to a paper
Check the material identity, formulation and analytical methods against the study methods. A product name or milligram amount alone does not demonstrate experimental equivalence. Published research does not establish the identity, purity or potency of a retail batch; batch-specific analytical documentation must be assessed separately.
For laboratory research only. Not for human or veterinary use. This guide is educational and contains no dosing, reconstitution or administration instructions.