NAD+
Also known as: Nicotinamide adenine dinucleotide
Quick summary
NAD+ is a coenzyme found in every living cell that shuttles electrons in energy metabolism and fuels enzymes such as sirtuins and PARPs. Research focus: cellular energy metabolism, aging biology and sirtuin signaling. This page leads with SRP's low-and-slow starting dose.
3D structure
Overview
NAD+ is a coenzyme found in every living cell that shuttles electrons in energy metabolism and fuels enzymes such as sirtuins and PARPs. Research interest centers on how NAD+ levels shift with age and how precursors raise them.
Looking for research material? Simple Research Peptides lists NAD+ 500 mg Cellular Metabolism Research Vial for laboratory research use.
Mechanism
NAD+ is a central cofactor in redox reactions and the substrate used up by sirtuins, PARPs and CD38. Its levels fall with age in animal tissues, which is why researchers study it.
Research areas
- cellular energy metabolism
- aging biology
- sirtuin signaling
Storage & reconstitution
Typically supplied as a lyophilized powder; keep sealed vials cold (refrigerated short term, frozen for long-term holding) and away from light. Laboratories commonly reconstitute with bacteriostatic or sterile water, swirling gently rather than shaking, and keep the solution refrigerated, using it within a few weeks.
Recommended starting dose (low and slow)
| Starting dose | Assessment step is 50 mg subcutaneously (once or three times weekly); also starts at 50 mg. lists 25-100 mg subcutaneous. |
|---|---|
| Frequency | Reported schedules: 1–3x weekly; IV 250–1000mg / SubQ 25–100mg / oral 250–500mg daily; 2–3× weekly; 2–3x weekly. Reported schedules vary. |
| Reconstitution | Examples: 500 mg vial + 5 mL bacteriostatic water = 100 mg/mL; 500mg vial + 5mL diluent (as listed). storage note: Reconstituted: refrigerate, protect from light, use within 2–4 weeks. |
Studied higher doses
Studies have used doses up to the amounts below. Higher doses can be dangerous. Whether a person can reach them safely depends on height, weight, activity level, training and pre-existing conditions. We recommend following the lower starting dose above, and contacting SRP with any questions.
| Highest amount reported in studies | 100 mg per subcutaneous dose in (agree). Intravenous figures (250-1,000 mg) and the 200 mg loading dose in are different routes/contexts. |
|---|---|
| Step-up schedules reported | Example: 50 mg (assessment), then 75 mg, then 100 mg two to three times weekly; an intensive 100-200 mg daily for 7-10 days is described as clinic-supervised only. |
Route and timing
Route: Subcutaneous or intramuscular injection; IV use is described in clinical settings.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks; blood pressure and resting heart rate, especially if combined with 5-Amino-1MQ.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is NAD+ studied for?
In research it is studied for cellular energy metabolism, aging biology and sirtuin signaling. NAD+ is a central cofactor in redox reactions and the substrate used up by sirtuins, PARPs and CD38.
How is NAD+ given in research?
Subcutaneous or intramuscular injection; IV use is described in clinical settings. See the dosing frequency block on this page for how often.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026