Humanin
Quick summary
A small peptide encoded in mitochondrial DNA, studied for its protective effects on cells in stress models. Research focus: mitochondrial-derived peptides and cell survival signaling. This page leads with SRP's low-and-slow starting dose.
Amino acid sequence (one-letter code): MAPRGFSCLLLLTSEIDLPVKRRA
Overview
A small peptide encoded in mitochondrial DNA, studied for its protective effects on cells in stress models.
Looking for research material? Simple Research Peptides lists Humanin 10 mg Vial for laboratory research use.
Mechanism
A peptide encoded in mitochondria that binds intracellular partners such as BAX and IGFBP3, as well as cell-surface receptors, to influence cell survival.
Research areas
- mitochondrial-derived peptides
- cell survival signaling
Storage & reconstitution
Supplied as a freeze-dried (lyophilized) powder in a sealed vial. Unopened vials are generally kept cold and away from light. Labs usually reconstitute it with bacteriostatic or sterile water, letting the liquid run down the vial wall and swirling gently instead of shaking. The solution is then kept refrigerated.
Recommended starting dose (low and slow)
| Starting dose | Low end of the studied range: 1 mg; 500 mcg; 500 mcg. |
|---|---|
| Frequency | Reported schedules: 2–3x weekly; Daily. Reported schedules vary. |
| Reconstitution | Examples: 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL; 20 mg vial + 2 mL water = 10 mg/mL. storage note: Reconstituted: refrigerate, use within 4 weeks. |
Studied higher doses
Studies have used doses up to the amounts below. Higher doses can be dangerous. Whether a person can reach them safely depends on height, weight, activity level, training and pre-existing conditions. We recommend following the lower starting dose above, and contacting SRP with any questions.
| Highest amount reported in studies | Top of the studied range: 4 mg; 1 mg; 2 mg. These are range tops, not verified ceilings. Reported amounts vary by 2x or more. |
|---|
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is Humanin studied for?
In research it is studied for mitochondrial-derived peptides and cell survival signaling. A peptide encoded in mitochondria that binds intracellular partners such as BAX and IGFBP3, as well as cell-surface receptors, to influence cell survival.
How is Humanin given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. See the dosing frequency block on this page for how often.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026