SS-20
Quick summary
A Szeto-Schiller tetrapeptide related to SS-31 that targets mitochondria but has no antioxidant dimethyltyrosine residue. Research focus: mitochondria-targeted peptides and cardiolipin interaction. SRP's starting dose for this compound is still pending.
Component structures:
Amino acid sequence (one-letter code): RFKF
Overview
A Szeto-Schiller tetrapeptide related to SS-31 that targets mitochondria but has no antioxidant dimethyltyrosine residue. Researchers often use it as a mechanistic comparison to SS-31. Listed by the store as contact-for-quote.
Looking for research material? Simple Research Peptides lists SS-20 50mg — Contact for a Quote for laboratory research use.
Mechanism
Targets cardiolipin like SS-31 but is not an antioxidant.
Research areas
- mitochondria-targeted peptides
- cardiolipin interaction
Storage & reconstitution
Supplied as a freeze-dried (lyophilized) powder in a sealed vial. Unopened vials are generally kept cold and away from light. Labs usually reconstitute it with bacteriostatic or sterile water, letting the liquid run down the vial wall and swirling gently instead of shaking. The solution is then kept refrigerated.
Recommended starting dose (low and slow)
| Starting dose | Pending - to be added by SRP |
|---|---|
| Frequency | Pending - to be added by SRP |
| Reconstitution | Pending - to be added by SRP |
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only.
Frequently asked questions
What is SS-20 studied for?
In research it is studied for mitochondria-targeted peptides and cardiolipin interaction. Targets cardiolipin like SS-31 but is not an antioxidant.
How is SS-20 given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. SRP has not yet published a frequency for this compound.
What amount should a researcher start with?
SRP has not yet published a starting dose for SS-20. Contact SRP before starting any research protocol, and do not guess.
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Last updated: October 19, 2026