Epitalon
Also known as: Epithalon, Epithalone, AEDG peptide
Quick summary
Epitalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly, designed after a pineal gland extract. Research focus: telomerase activity, telomere length in cell culture and replicative lifespan of fibroblasts. This page leads with SRP's low-and-slow starting dose.
3D structure
Overview
Epitalon is the synthetic tetrapeptide Ala-Glu-Asp-Gly, designed after a pineal gland extract. Work from the St. Petersburg Institute of Bioregulation and Gerontology reports telomerase activation in cultured human cells. Most of the evidence is cell culture and rodent work.
Looking for research material? Simple Research Peptides lists Epitalon (10 mg Vial) for laboratory research use.
Mechanism
A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a pineal gland extract. Cell studies link it to telomerase activity and changes in chromatin.
Research areas
- telomerase activity
- telomere length in cell culture
- replicative lifespan of fibroblasts
Storage & reconstitution
Supplied as a lyophilized powder; keep sealed, dry and away from light, ideally frozen or refrigerated for long-term holding. Laboratories typically reconstitute with bacteriostatic or sterile water, swirling gently rather than shaking, then hold the solution refrigerated (2–8 °C) and use it within the window set by their own stability protocol.
Recommended starting dose (low and slow)
| Starting dose | 5 mg once daily (standard short cycle; ranges begin at 5 mg). |
|---|---|
| Frequency | Reported schedules: daily for 10–20 days, cycled 1–2x yearly; 5–10mg daily x10 days; Daily. |
| Reconstitution | Examples: 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL; 10mg vial + 2mL diluent (as listed). storage note: Reconstituted: refrigerate, used within 4 weeks. |
Studied higher doses
Studies have used doses up to the amounts below. Higher doses can be dangerous. Whether a person can reach them safely depends on height, weight, activity level, training and pre-existing conditions. We recommend following the lower starting dose above, and contacting SRP with any questions.
| Highest amount reported in studies | 10 mg per day (agree), for 10-20 day cycles. |
|---|---|
| Step-up schedules reported | No step-up described; offers two fixed cycles: 5 mg daily for 20 days, or 10 mg daily for 10 days, each repeated 2-3 times a year. |
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is Epitalon studied for?
In research it is studied for telomerase activity, telomere length in cell culture and replicative lifespan of fibroblasts. A synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a pineal gland extract.
How is Epitalon given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. See the dosing frequency block on this page for how often.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026