Kisspeptin
Also known as: Kisspeptin-10, Kisspeptin-54, Metastin
Quick summary
Kisspeptins are peptides from the KISS1 gene that activate the GPR54 (KISS1R) receptor. Research focus: GnRH/LH/FSH axis, reproductive endocrinology and GPR54 signaling. This page leads with SRP's low-and-slow starting dose.
Amino acid sequence (one-letter code): YNWNSFGLRF
Overview
Kisspeptins are peptides from the KISS1 gene that activate the GPR54 (KISS1R) receptor. They sit at the top of the reproductive hormone axis. Kisspeptin-54 is the full-length form, and kisspeptin-10 is the short active fragment.
Looking for research material? Simple Research Peptides lists Kisspeptin-10 (10 mg Vial) for laboratory research use.
Mechanism
Kisspeptins activate KISS1R on GnRH neurons and are a key upstream switch for the reproductive axis.
Research areas
- GnRH/LH/FSH axis
- reproductive endocrinology
- GPR54 signaling
Storage & reconstitution
Supplied as a lyophilized powder; keep sealed, dry and away from light, ideally frozen or refrigerated for long-term holding. Laboratories typically reconstitute with bacteriostatic or sterile water, swirling gently rather than shaking, then hold the solution refrigerated (2–8 °C) and use it within the window set by their own stability protocol.
Recommended starting dose (low and slow)
| Starting dose | Low end of the studied range: 100 mcg; 100 mcg; 100 mcg; 50 mcg; 50 mcg. |
|---|---|
| Frequency | Reported schedules: 1–3x weekly; 100–200mcg daily; 1–2× daily; 1–2x daily. Reported schedules vary. |
| Reconstitution | Examples: 5 mg vial + 2 mL bacteriostatic water = 2.5 mg/mL; 10 mg vial + 2 mL water = 5 mg/mL; 10mg vial + 2mL diluent (as listed). storage note: Reconstituted: refrigerate, used within 4 weeks. |
Studied higher doses
Studies have used doses up to the amounts below. Higher doses can be dangerous. Whether a person can reach them safely depends on height, weight, activity level, training and pre-existing conditions. We recommend following the lower starting dose above, and contacting SRP with any questions.
| Highest amount reported in studies | Top of the studied range: 200 mcg; 200 mcg; 200 mcg; 200 mcg; 200 mcg. These are range tops, not verified ceilings. |
|---|
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Very short, a few minutes.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks; blood pressure readings; relevant reproductive hormones.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is Kisspeptin studied for?
In research it is studied for GnRH/LH/FSH axis, reproductive endocrinology and GPR54 signaling. Kisspeptins activate KISS1R on GnRH neurons and are a key upstream switch for the reproductive axis.
How is Kisspeptin given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. See the dosing frequency block on this page for how often.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026