Argireline (Acetyl Hexapeptide-3)
Quick summary
A hexapeptide modeled on part of the SNAP-25 protein, studied in cosmetic science for its effects on how nerve signals reach muscle. Research focus: SNARE complex research and cosmetic formulation science. SRP's starting dose for this compound is still pending.
2D structure
Overview
A hexapeptide modeled on part of the SNAP-25 protein, studied in cosmetic science for its effects on how nerve signals reach muscle.
Looking for research material? Simple Research Peptides lists Argireline 10mg Research Peptide Vial for laboratory research use.
Mechanism
Mimics the N-terminal end of SNAP-25 and competes for a place in the SNARE complex, which reduces neurotransmitter release.
Research areas
- SNARE complex research
- cosmetic formulation science
Storage & reconstitution
Supplied as a freeze-dried (lyophilized) powder in a sealed vial. Unopened vials are generally kept cold and away from light. Labs usually reconstitute it with bacteriostatic or sterile water, letting the liquid run down the vial wall and swirling gently instead of shaking. The solution is then kept refrigerated.
Recommended starting dose (low and slow)
| Starting dose | Pending - to be added by SRP |
|---|---|
| Frequency | Twice daily, topical. |
| Reconstitution | Pending - to be added by SRP |
Route and timing
Route: Topical (applied to the skin).
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: For topical use, usually none beyond a patch test; for injectable forms, CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is Argireline (Acetyl Hexapeptide-3) studied for?
In research it is studied for SNARE complex research and cosmetic formulation science. Mimics the N-terminal end of SNAP-25 and competes for a place in the SNARE complex, which reduces neurotransmitter release.
How is Argireline (Acetyl Hexapeptide-3) given in research?
Topical (applied to the skin). See the dosing frequency block on this page for how often.
What amount should a researcher start with?
SRP has not yet published a starting dose for Argireline (Acetyl Hexapeptide-3). Contact SRP before starting any research protocol, and do not guess.
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Last updated: October 19, 2026