ARA-290
Also known as: Cibinetide
Quick summary
ARA-290 is an 11-amino-acid peptide modeled on a surface region of erythropoietin. Research focus: innate repair receptor signaling, corneal nerve fiber imaging and small nerve fiber research. This page leads with SRP's low-and-slow starting dose.
2D structure
Overview
ARA-290 is an 11-amino-acid peptide modeled on a surface region of erythropoietin. It was built to engage the tissue-protective innate repair receptor without stimulating red blood cell production. Clinical research has focused on small nerve fiber measurements.
Looking for research material? Simple Research Peptides lists ARA-290 (10 mg Vial) for laboratory research use.
Mechanism
An 11-amino-acid peptide based on erythropoietin that activates the innate repair receptor (EPOR/CD131) but does not stimulate red blood cell production.
Research areas
- innate repair receptor signaling
- corneal nerve fiber imaging
- small nerve fiber research
Storage & reconstitution
Supplied as a lyophilized powder; keep sealed, dry and away from light, ideally frozen or refrigerated for long-term holding. Laboratories typically reconstitute with bacteriostatic or sterile water, swirling gently rather than shaking, then hold the solution refrigerated (2–8 °C) and use it within the window set by their own stability protocol.
Recommended starting dose (low and slow)
| Starting dose | Low end of the studied range: 1 mg; 4 mg. |
|---|---|
| Frequency | Once daily, subcutaneous. |
| Reconstitution | Examples: 10 mg vial + 2 mL bacteriostatic water = 5 mg/mL; 16mg vial + 5mL diluent (as listed). Different water volumes can be used; that only changes the draw volume, not the amount of peptide. storage note: Reconstituted: refrigerate, use within 3–4 weeks. |
Studied higher doses
Studies have used doses up to the amounts below. Higher doses can be dangerous. Whether a person can reach them safely depends on height, weight, activity level, training and pre-existing conditions. We recommend following the lower starting dose above, and contacting SRP with any questions.
| Highest amount reported in studies | Top of the studied range: 4 mg; 4 mg. These are range tops, not verified ceilings. |
|---|
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Very short, a few minutes in the blood.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is ARA-290 studied for?
In research it is studied for innate repair receptor signaling, corneal nerve fiber imaging and small nerve fiber research. An 11-amino-acid peptide based on erythropoietin that activates the innate repair receptor (EPOR/CD131) but does not stimulate red blood cell production.
How is ARA-290 given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. See the dosing frequency block on this page for how often.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026