SS-31 (Elamipretide) Research Peptide

SS-31 (Elamipretide) Research Peptide 10mg

SS-31 (also known as Elamipretide or Bendavia) is a cell-permeable, mitochondria-targeted tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH2) that accumulates in the inner mitochondrial membrane based on membrane potential. It binds to cardiolipin, a unique mitochondrial phospholipid, stabilizing mitochondrial structure and function. SS-31 has been extensively studied for its role in protecting mitochondrial function under conditions of oxidative stress, ischemia-reperfusion injury, and aging-related mitochondrial dysfunction.

Research Applications

• Mitochondrial function and membrane stability research
• Ischemia-reperfusion injury models
• Cardiolipin stabilization and mitochondrial structure studies
• Oxidative stress protection research
• Aging-related mitochondrial dysfunction studies

Quality Specifications

• Purity: ≥98% (HPLC verified)
• Compound: SS-31 (Elamipretide)
• Molecular Weight: 1639.9 Da
• Form: Lyophilized powder
• Storage: -20°C, protect from light
• COA: Batch-specific, ISO-accredited laboratory

Frequently Asked Questions

Q: How does SS-31 target mitochondria?
A: SS-31 is a Szeto-Schiller (SS) peptide with alternating aromatic and basic residues that make it cell-permeable and cause accumulation in mitochondria based on membrane potential (~150-180 mV negative inside).

Q: What is cardiolipin and why does it matter?
A: Cardiolipin is a unique phospholipid found only in mitochondrial inner membranes, essential for oxidative phosphorylation and cristae structure. SS-31 binds cardiolipin, stabilizing mitochondrial architecture.

Q: What distinguishes SS-31 from other mitochondrial peptides?
A: Unlike MOTS-C (mitochondria-encoded) or other peptides, SS-31 specifically targets the inner mitochondrial membrane and cardiolipin, offering a unique mechanistic approach to mitochondrial protection research.