TRH (Protirelin)
Quick summary
Thyrotropin-releasing hormone, a three-amino-acid peptide from the hypothalamus. Research focus: hypothalamic–pituitary–thyroid axis and CNS neuropeptide research. SRP's starting dose for this compound is still pending.
3D structure
Overview
Thyrotropin-releasing hormone, a three-amino-acid peptide from the hypothalamus. It is a classic tool for studying the thyroid axis and its effects in the central nervous system.
Looking for research material? Simple Research Peptides lists TRH (Protirelin) 25mg for laboratory research use.
Mechanism
Activates TRH receptors on pituitary thyrotroph cells and causes TSH release.
Research areas
- hypothalamic–pituitary–thyroid axis
- CNS neuropeptide research
Storage & reconstitution
Supplied as a freeze-dried (lyophilized) powder in a sealed vial. Unopened vials are generally kept cold and away from light. Labs usually reconstitute it with bacteriostatic or sterile water, letting the liquid run down the vial wall and swirling gently instead of shaking. The solution is then kept refrigerated.
Recommended starting dose (low and slow)
| Starting dose | Pending - to be added by SRP |
|---|---|
| Frequency | Pending - to be added by SRP |
| Reconstitution | Pending - to be added by SRP |
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Very short, a few minutes.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks; the relevant reproductive hormones (for example LH, FSH, total and free testosterone or estradiol) and prolactin.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is TRH (Protirelin) studied for?
In research it is studied for hypothalamic–pituitary–thyroid axis and CNS neuropeptide research. Activates TRH receptors on pituitary thyrotroph cells and causes TSH release.
How is TRH (Protirelin) given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. SRP has not yet published a frequency for this compound.
What amount should a researcher start with?
SRP has not yet published a starting dose for TRH (Protirelin). Contact SRP before starting any research protocol, and do not guess.
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Last updated: October 19, 2026