MGF (Mechano Growth Factor)
Quick summary
A peptide based on an IGF-1 splice variant that is produced in muscle after mechanical load. Research focus: IGF-1 splice variants and muscle repair models. This page leads with SRP's low-and-slow starting dose.
Amino acid sequence (one-letter code): YQPPSTNKNTKSQRRKGSTFEEHK
Overview
A peptide based on an IGF-1 splice variant that is produced in muscle after mechanical load.
Looking for research material? Simple Research Peptides lists MGF for laboratory research use.
Mechanism
An IGF-1 splice variant with a distinct E-domain peptide. It is linked to activating muscle stem (satellite) cells.
Research areas
- IGF-1 splice variants
- muscle repair models
Storage & reconstitution
Supplied as a freeze-dried (lyophilized) powder in a sealed vial. Unopened vials are generally kept cold and away from light. Labs usually reconstitute it with bacteriostatic or sterile water, letting the liquid run down the vial wall and swirling gently instead of shaking. The solution is then kept refrigerated.
Recommended starting dose (low and slow)
| Starting dose | Low end of the studied range: 100 mcg. |
|---|---|
| Frequency | Pending - to be added by SRP |
| Reconstitution | Examples: 5 mg vial + 3 mL water = 1.67 mg/mL. |
Studied higher doses
Studies have used doses up to the amounts below. Higher doses can be dangerous. Whether a person can reach them safely depends on height, weight, activity level, training and pre-existing conditions. We recommend following the lower starting dose above, and contacting SRP with any questions.
| Highest amount reported in studies | Top of the studied range: 300 mcg. These are range tops, not verified ceilings. |
|---|
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks; IGF-1, fasting glucose and HbA1c.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is MGF (Mechano Growth Factor) studied for?
In research it is studied for IGF-1 splice variants and muscle repair models. An IGF-1 splice variant with a distinct E-domain peptide.
How is MGF (Mechano Growth Factor) given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. SRP has not yet published a frequency for this compound.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026