5-Amino-1MQ
Also known as: 5-amino-1-methylquinolinium
Quick summary
A small-molecule quinolinium compound (not a peptide) studied as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Research focus: NNMT inhibition, diet-induced obesity mouse models and gut microbiome studies. This page leads with SRP's low-and-slow starting dose.
3D structure
Overview
A small-molecule quinolinium compound (not a peptide) studied as an inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT). Labs use it to probe how NNMT activity links to fat-cell metabolism and NAD+ pathways.
Looking for research material? Simple Research Peptides lists 5-Amino-1MQ for laboratory research use.
Mechanism
A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in fat tissue.
Research areas
- NNMT inhibition
- diet-induced obesity mouse models
- gut microbiome studies
Storage & reconstitution
Typically supplied as a lyophilized powder; keep sealed vials cold (refrigerated short term, frozen for long-term holding) and away from light. Laboratories commonly reconstitute with bacteriostatic or sterile water, swirling gently rather than shaking, and keep the solution refrigerated, using it within a few weeks.
Recommended starting dose (low and slow)
| Starting dose | 30 units (0.3 mL on a 1 mL insulin-type syringe) twice daily, from a vial reconstituted with 3 mL bacteriostatic water. |
|---|---|
| Frequency | Twice daily. |
| Reconstitution | Reconstitute with 3 mL bacteriostatic water. |
Low and slow. Do not raise the dose just because higher amounts have been studied. 5-Amino-1MQ is often used alongside NAD+; maxing out both together can cause marked blood pressure and heart rate increases and a very sick feeling. Contact SRP with any questions.
Route and timing
Route: Subcutaneous injection after reconstitution is the route most often described in research protocols.
Timing: Pending - to be added by SRP
Cycle length and repeat
Pending - to be added by SRP
Half-life
Approximate, for Bobby's review: Not well characterized in published research.
Side effects
Pending - to be added by SRP
Suggested bloodwork and monitoring
Draft, for Bobby's review: CBC and comprehensive metabolic panel (kidney and liver function, electrolytes) before starting and again after a few weeks; blood pressure and resting heart rate, especially if combined with NAD+.
Cautions
Pending - to be added by SRP
Reconstitution calculator
Math aid only. It converts the numbers you enter; it is not dosing advice. For research use only. Prefilled with this page's vial size, reconstitution and low-and-slow starting dose where known; change any value.
Frequently asked questions
What is 5-Amino-1MQ studied for?
In research it is studied for NNMT inhibition, diet-induced obesity mouse models and gut microbiome studies. A small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in fat tissue.
How is 5-Amino-1MQ given in research?
Subcutaneous injection after reconstitution is the route most often described in research protocols. See the dosing frequency block on this page for how often.
What amount should a researcher start with?
This page lists SRP's low-and-slow starting dose in the Recommended starting dose section. Higher amounts that appear in studies are listed separately with their safety context. Start with the lower dose and contact SRP with any questions.
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Last updated: October 19, 2026