:root{--blue:#19d3ff;--blue2:#0a7cff;--steel:linear-gradient(135deg,#f4f6f8,#9aa3ad 40%,#e6e9ec 55%,#6f7882);--silver:#c9d0d6}
*{box-sizing:border-box}body{margin:0;background:#000;color:#dfe5ea;font:16px/1.6 system-ui,Segoe UI,Arial,sans-serif;min-height:100vh}
.molecules{position:fixed;inset:0;z-index:-1;opacity:.35;background:url(molecule.svg) repeat;background-size:420px;animation:drift 90s linear infinite}
@keyframes drift{to{background-position:420px 840px}}
header{text-align:center;padding:24px 16px 10px;border-bottom:1px solid #1d2a33;background:radial-gradient(ellipse at top,#06223a 0,#000 70%)}
nav a{color:var(--blue);margin:0 12px;text-decoration:none;font-weight:600;text-shadow:0 0 8px var(--blue2)}nav a:hover{color:#fff}
.tools{display:flex;gap:10px;justify-content:center;flex-wrap:wrap;margin:14px auto 6px;max-width:760px;position:relative}
input,select{background:#0b0f13;color:#fff;border:1px solid var(--blue);border-radius:10px;padding:10px 14px;font-size:15px;box-shadow:0 0 10px #19d3ff44;min-width:260px;flex:1}
#res{position:absolute;top:46px;left:0;right:0;z-index:9;background:#05090d;border:1px solid var(--blue2);border-radius:10px;display:none;text-align:left;max-height:320px;overflow:auto}
#res a{display:block;padding:8px 14px;color:#dfe5ea;text-decoration:none}#res a:hover{background:#0a2840}
.notice{margin:14px auto;max-width:1000px;text-align:center;font-weight:700;color:#000;background:var(--steel);border:2px solid var(--blue);border-radius:10px;padding:10px;box-shadow:0 0 14px #19d3ff66}
main{max-width:1100px;margin:auto;padding:10px 16px 30px}
.hero h1,.card h1{font-size:clamp(26px,4vw,40px);margin:.3em 0;color:#fff;text-shadow:0 0 14px var(--blue2)}
h2{color:var(--blue);border-bottom:1px solid #1e3443;padding-bottom:4px;margin-top:1.5em}
.grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(210px,1fr));gap:12px}
.tile{display:block;padding:14px;border-radius:12px;background:linear-gradient(160deg,#10161c,#05080b);border:1px solid #2b3a46;text-decoration:none;color:#fff;transition:.2s}
.tile:hover{border-color:var(--blue);box-shadow:0 0 16px #19d3ff77;transform:translateY(-2px)}.tile span{display:block;color:var(--silver);font-size:13px}
.card{background:#070b0fe6;border:1px solid #23323d;border-radius:14px;padding:20px 24px;margin:14px 0;box-shadow:inset 0 1px 0 #ffffff14}
.cat{display:inline-block;font-size:12px;letter-spacing:.1em;text-transform:uppercase;padding:2px 10px;border-radius:20px;background:var(--steel);color:#000;font-weight:700}
.btn{display:inline-block;margin:8px 0;padding:10px 18px;border-radius:10px;background:linear-gradient(90deg,var(--blue2),var(--blue));color:#000;font-weight:800;text-decoration:none;box-shadow:0 0 14px var(--blue)}
.tw{overflow-x:auto}table{border-collapse:collapse;width:100%;font-size:14px}th{background:var(--steel);color:#000;text-align:left}th,td{padding:8px 10px;border:1px solid #23323d;vertical-align:top}td a{color:var(--blue)}
.muted{color:#9aa6b0}.small{font-size:13px}a{color:var(--blue)}
footer{text-align:center;color:var(--silver);font-size:13px;padding:20px;border-top:1px solid #1d2a33}
body{background-color:#000;background-image:linear-gradient(rgba(0,0,0,.62),rgba(0,0,0,.78)),var(--bg,none);background-size:cover;background-position:center top;background-attachment:fixed}
.card{background:rgba(3,8,14,.84);backdrop-filter:blur(2px)}
.figs{display:flex;flex-wrap:wrap;gap:14px;margin:10px 0}
figure.mol{margin:0;max-width:240px;background:rgba(0,0,0,.5);border:1px solid #124a66;border-radius:10px;padding:6px;box-shadow:0 0 14px #19d3ff33}
figure.mol img{display:block;width:220px;height:auto;max-width:100%}
figure.mol figcaption{font-size:11px;line-height:1.35;color:#9fb4c2;word-break:break-all}
figure.mol.seq{max-width:340px}figure.mol.seq img{width:320px}

/* brand header */
.brand{position:relative;display:inline-block;max-width:100%;isolation:isolate}
.logo{display:block;margin:0 auto;max-width:min(420px,90vw);height:auto;filter:drop-shadow(0 0 18px #0a7cffaa)}
.brand::after{content:"";position:absolute;inset:0;pointer-events:none;-webkit-mask:url(logo.webp) center/contain no-repeat;mask:url(logo.webp) center/contain no-repeat;background:linear-gradient(105deg,transparent 40%,rgba(255,255,255,.85) 50%,transparent 60%) 160% 0/250% 100% no-repeat;animation:sheenL 9s ease-in-out infinite}
@keyframes sheenL{0%{background-position:160% 0}22%,100%{background-position:-60% 0}}
.tag{position:relative;isolation:isolate;display:block;max-width:1100px;margin:6px auto 14px;padding:0 10px;text-align:center;font-weight:900;text-transform:uppercase;letter-spacing:.1em;line-height:1.25;font-size:clamp(15px,3.1vw,34px);text-wrap:balance;overflow-wrap:anywhere;
 color:transparent;-webkit-text-fill-color:transparent;-webkit-background-clip:text;background-clip:text;
 background:linear-gradient(105deg,transparent 42%,rgba(255,255,255,.95) 50%,transparent 58%) 160% 0/250% 100% no-repeat,
  repeating-linear-gradient(0deg,rgba(255,255,255,.28) 0 1px,rgba(0,0,0,.22) 1px 2px),
  linear-gradient(180deg,#ffffff 0%,#c4cbd2 22%,#8d96a0 48%,#e9edf0 62%,#7b848e 85%,#b9c1c8 100%);
 -webkit-background-clip:text;background-clip:text;animation:sheenT 9s ease-in-out infinite;animation-delay:.35s;filter:drop-shadow(0 -1px 0 rgba(255,255,255,.55)) drop-shadow(0 1px 0 rgba(0,0,0,.8))}
.tagwrap{position:relative;isolation:isolate;max-width:1100px;margin:6px auto 14px}.tagwrap .tag{margin:0}.tagwrap::before{content:attr(data-text);position:absolute;inset:0;padding:0 10px;z-index:-1;text-align:center;font-weight:900;text-transform:uppercase;letter-spacing:.1em;line-height:1.25;font-size:clamp(15px,3.1vw,34px);text-wrap:balance;overflow-wrap:anywhere;color:#19d3ff;-webkit-text-fill-color:#19d3ff;background:none;filter:blur(10px);opacity:.6;animation:breathe 4.5s ease-in-out infinite;pointer-events:none}
@keyframes sheenT{0%{background-position:160% 0,0 0,0 0}22%,100%{background-position:-60% 0,0 0,0 0}}
@keyframes breathe{0%,100%{opacity:.35;filter:blur(12px)}50%{opacity:.95;filter:blur(7px)}}
@media (max-width:600px){.tag,.tagwrap::before{letter-spacing:.05em}}
@media (prefers-reduced-motion:reduce){.brand::after,.tag,.tagwrap::before{animation:none}.brand::after{display:none}.tag{background-position:160% 0,0 0,0 0}.tagwrap::before{opacity:.6}}
/* fx + calculator */
.fx{position:fixed;inset:0;width:100%;height:100%;z-index:-1;pointer-events:none;opacity:.55}
.card{transition:box-shadow .3s,border-color .3s,transform .3s}.card:hover{border-color:#19d3ff88;box-shadow:0 0 22px #19d3ff33,inset 0 1px 0 #ffffff14}
.btn{transition:box-shadow .25s,transform .25s}.btn:hover{box-shadow:0 0 18px #19d3ffaa;transform:translateY(-1px)}
main>*{animation:rise .6s ease-out both}@keyframes rise{from{transform:translateY(12px)}to{transform:none}}
.freq{display:flex;gap:14px;align-items:center;flex-wrap:wrap;margin:14px 0;padding:12px 16px;border:1px solid var(--blue);border-radius:12px;background:linear-gradient(90deg,#06223acc,#05080bcc);box-shadow:0 0 14px #19d3ff33}
.freq b{color:var(--blue);text-transform:uppercase;letter-spacing:.08em;font-size:13px}.freq span{font-size:17px;color:#fff}
.calc{border:1px solid #2b3a46;border-radius:14px;padding:18px;background:linear-gradient(160deg,#0b1218ee,#04070aee);margin:16px 0}
.calc h2{margin-top:0}.calc-in{display:grid;grid-template-columns:repeat(auto-fit,minmax(160px,1fr));gap:12px}
.calc label{display:flex;flex-direction:column;gap:4px;font-size:13px;color:var(--silver);text-transform:uppercase;letter-spacing:.05em}
.calc input,.calc select{min-width:0;width:100%}.calc .dose{display:flex;gap:6px}.calc .dose select{width:80px;flex:0 0 80px}
.calc-out{display:grid;grid-template-columns:repeat(auto-fit,minmax(170px,1fr));gap:12px;margin:14px 0}
.calc-out div{border:1px solid #23323d;border-radius:10px;padding:10px 12px;background:#05080b}
.calc-out span{display:block;font-size:12px;color:var(--silver);text-transform:uppercase}.calc-out b{display:block;font-size:22px;color:#fff;text-shadow:0 0 10px #19d3ff}.calc-out small{color:#8fa0ad}
.calc .warn{grid-column:1/-1;margin:0;color:#ffd166}.syr svg{width:100%;height:auto;max-height:170px;display:block}
.syr-fill{transition:width .9s cubic-bezier(.2,.8,.2,1)}.syr-plg{transition:transform .9s cubic-bezier(.2,.8,.2,1)}
.calc-note{font-size:13px;color:#ffd166;border-left:3px solid #ffd166;padding-left:10px}
.sidefx{border-left:3px solid var(--blue);padding-left:12px}
@media (prefers-reduced-motion:reduce){.fx{display:none}main>*{animation:none}.syr-fill,.syr-plg,.card,.btn{transition:none}.card:hover,.btn:hover{transform:none}}
.tldr{border:1px solid var(--blue);border-radius:12px;padding:6px 16px 10px;margin:12px 0;background:linear-gradient(135deg,#06223acc,#05080bcc);box-shadow:0 0 14px #19d3ff33}.tldr h2{margin:.4em 0 .2em}
.draft{display:inline-block;font-size:12px;font-weight:700;color:#000;background:#ffd166;border-radius:6px;padding:1px 7px;margin-right:4px}
.faq details{border:1px solid #23323d;border-radius:10px;padding:10px 14px;margin:8px 0;background:#05080b;transition:border-color .2s}.faq details[open],.faq details:hover{border-color:var(--blue)}
.faq summary{cursor:pointer;font-weight:700;color:#fff}.faq p{margin:.6em 0 0}.updated{margin-top:18px}
.studynote{border:1px solid #ffd166;border-radius:10px;padding:10px 14px;background:#1a1405cc;color:#ffe3a0}